NCI Investigator-Initiated Early Phase Cancer Clinical Trials (R01, Clinical Trial Required) Application budgets are limited to no more than $499,999 in direct costs per year. - June 5 and October 5, 2026. National Institutes of Health (NIH)-R01 Research Project Grant* NCI seeks early-phase (0–II) investigator-initiated clinical trials on cancer diagnostics and therapeutics relevant to DCTD and OHAM.