UNDERSTANDING THE FOREIGN BODY RESPONSE IN ISLET CELL REPLACEMENT: ACCELERATING CLINICAL TRANSLATION

The aim is to support innovative research that advances the clinical translation of biomaterial-based immune- isolation strategies for islet cell replacement therapy in T1D. Preference will be given to proposals that: Use GMP-compatible biomaterials to enhance clinical relevance, Include benchmarking against biomaterials/devices with prior clinical testing, Use large animal models and NHPs, Involve collaborations between teams that have tested devices in preclinical models and can compile data towards better mechanistic understanding of the FBR or Build on previous clinical studies and/or explanted devices to elucidate mechanisms of human FBR